منابع مشابه
Adjuvant therapy for High-risk Melanoma
Introduction High-risk resected melanoma signifies a group of patients that carries a risk of melanoma recurrence and death after initial surgical resection that may be defined as 35% to 40% or higher and includes patients with American Joint committee on cancer (AJcc) stages IIb, IIc, III, and IV. the development of local or regional recurrence after initial surgical management portends an eve...
متن کاملAdjuvant therapy for high-risk melanoma
Adjuvant vaccine trials in melanoma thus far have failed, results ranging from ineffective (three randomized controlled trial (RCTs) [1]) to harmful (three RCTs [2–4]). Two large trials with Canvaxin ended early because of a detrimental outcome for the vaccine arm. Two large trials with the GMK vaccine (ganglioside GM2/KLH/QS-21) were also stopped early because of inferior outcome in the vaccin...
متن کاملUpdate on adjuvant interferon therapy for high-risk melanoma.
Melanoma is almost 100% curable when diagnosed early, but when metastatic to distant organs, it is associated with a poor survival. The interferons have shown the mostpromise in the treatment of melanoma and interferon-alpha has been the most extensively studied. In recent trials, interferon alfa-2b (Intron A) administered at maximally tolerated doses for 1 year produced improvements in both re...
متن کاملHigh-risk surgically resected pediatric melanoma and adjuvant interferon therapy.
BACKGROUND Pediatric patients with high-risk surgically resected melanoma are at risk for relapse, yet little is known about these young patients and how they tolerate high-dose interferon therapy. PROCEDURE We reviewed medical records of patients (< or =18 years) with high-risk melanoma referred to the University of Michigan Pediatric Hematology-Oncology service between January 1989 and July...
متن کاملHigh frequency of brain metastases after adjuvant therapy for high‐risk melanoma
The incidence of CNS progression in patients with high-risk regional melanoma (stages IIIAN2a-IIIC) is not well characterized. Data from the S0008 trial provided an opportunity to examine the role of CNS progression in treatment failure and survival. All patients were surgically staged. Following wide excision and full regional lymphadenectomy, patients were randomized to receive adjuvant bioch...
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ژورنال
عنوان ژورنال: European Journal of Cancer Supplements
سال: 2013
ISSN: 1359-6349
DOI: 10.1016/j.ejcsup.2013.07.014